Pesquisa sobre:
INSULIN RECEPTOR SUBSTRATE PROTEINS
Descritores Encontrados:
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DeCS
Descritor
Inglês
:
Insulin Receptor Substrate Proteins
Descritor
Espanhol
:
Proteínas Sustrato del Receptor de Insulina
Descritor
Português
:
Proteínas Substratos do Receptor de Insulina
Categoria:
D12.644.360.024.301
D12.776.157.057.039
D12.776.476.024.382
Definição
Inglês
:
A structurally-related group of signaling
proteins
that are phosphorylated by the
INSULIN
RECEPTOR PROTEIN-TYROSINE KINASE. The
proteins
share in common an N-terminal PHOSPHOLIPID-binding domain, a phosphotyrosine-binding domain that interacts with the phosphorylated
INSULIN
RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon
tyrosine
phosphorylation
insulin receptor substrate proteins
interact with specific SH2 DOMAIN-containing
proteins
that are involved in
insulin
receptor signaling.
Nota Histórica
Inglês
:
2009(1992)
Qualificadores Permitidos
Inglês
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número do Registro:
53148
Identificador Único:
D055504
Ocorrência na BVS
:
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